“Chemotherapy usually works by inducing DNA damage that leads to cell death. However, rather than dying after chemotherapy, some tumour cells enter an inactive state, termed senescence, in which they are alive but have permanently stopped dividing1. Although senescence in normal cells drives ageing and tissue degeneration2, cancer-therapy-induced senescence is associated with positive clinical outcomes3. Understanding the factors that drive the senescence of tumour cells might thus aid the development of new anticancer treatments. Writing in Cell, Hsu et al.4 shed light on a previously unknown aspect of how chemotherapy-induced entry into senescence is controlled.”
More on A dynamic view of chemotherapy effectiveness (2019) by Liu & Hemann via Nature.